| |
DNA Repair and Damage Responses
P1
Double Strand Break Repair inHuman Mitochondrial Extracts
Hunter SE, Collins L, Van Houten B. National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.
P3
The Role of the DDB1-CUL4BDDB2 E3 Ubiquitin Ligase in Nucleotide Excision Repair
Kapetanaki MG1,2, Guerrero-Santoro J1,2, Hsieh CL1,2, Gorbachinsky I1, Levine AS1,2, Rapic-Otrin V1,2. 1Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, 2Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, United States.
P5
Age-Dependent Accumulation of Mitochondrial and Nuclear DNA Damage in Spermatogenic Cells Derived from APE1+/- Mice
Acevedo-Torres K1, Walter C2, Ayala-Torres S1, Torres-Ramos CA1. 1University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, 2University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.
P7
Use of a Werner Helicase Knockdown Cell Line to Investigate the Role of WRN in Mammalian Recombination
Rahn JJ, Della-Coletta L., Lowery M, Limanni T, Adair G, Nairn R. UT MD Anderson Cancer Center, Science Park Research Division, Smithville, TX, United States.
P9
hMSH6: DNA Mismatch Repair or Damage Signaling?
Kaliyaperumal S, Williams K. University of Toledo Health Science Campus, Toledo, OH, United States.
P11
Role of Post-translational Modifications in the Regulation of SV40 DNA Replication
Thompson EG, Henricksen LA, Dixon K. University of Arizona, Tucson, AZ, United States.
P13
Radiation Quality Dependent Specific ATM-Mediated Phosphorylation
Whalen MK, Gurai SK, Zahed-Kargaran H, Pluth JM. Lawrence Berkeley National Lab, Berkeley, CA, United States.
P15
Towards Personalized Chemotherapeutics: Exploring Variations in DNA Damage/Repair in Cells and Tumors Treated with Carboplatin Using Accelerator Mass Spectrometry
Henderson PT1,2, Li T1, Zhang H1, Malfatti M2, Ma X3, Turteltaub KW2, de Vere White RW2, Pan C-X1. 1Biosciences and Biotechnology Division, Chemistry, Materials Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States, 2Department of Internal Medicine, Division of Hematology Oncology, School of Medicine, University of California, Davis, Davis, CA, United States, 3Department of Biostatistics, School of Public Health, University of California, Los Angeles, CA, United States.
Epigenetics
P17
Multiple Generational Exposure of Drosophila melanogaster to Ethanol Increased Toxic Effects of Chlorophenoxy Herbicides in Later Generations
van Gijssel HE, Gienger HM, Bata MA, Dobmeier AD, Blunck BM. Valley City State University, Valley City, ND, United States.
P19
Oxidative Stress, Antioxidant Defense System During Hepatocarcinogenesis Induced by Dietary Methyl Deficiency in Mice
Montgomery BA, Bagnyukova TV, Pogribny IP. National Center for Toxicological Research, Jefferson, AR, United States.
P21
Susceptibility of Y Chromosome to DNA Damage
Xun L, Jia J, Wei F, Robbins w. UCLA, Los Angeles, CA, United States.
P23
Epigenetic Regulation of Somatic and Transgenerational Response to Environmental Stress in Plants
Boyko A, Titov V, Yao Y, Kovalchuk I. University of Lethbridge, Lethbridge, AB, Canada.
Mutagenesis and Carcinogenesis
P25
The Lowest Dose of Ionizing Radiation Detectable Using FISH Whole Chromosome Painting
Tucker JD, Luckinbill LS. Wayne State University, Detroit, MI, United States.
P27
Predicting the Genetic Toxicity of Kinase Inhibitors Based Upon Kinase Inhibitory Profiles
Olaharski AJ1, Gonzaludo N1, Goldstein D1, Bitter H1, Kirchner S2, Uppal H1, Kolaja K1. 1Roche Palo Alto LLC, Palo Alto, CA, United States, 2Hoffman-La Roche, Basel, Switzerland.
P29
Development of a New Array Comparative Genomic Hybridization Tool for High Resolution Analysis of Mouse Chromosome 11
Fuscoe JC1, Han T1, Wang J2, Sawyer J3, Mei N4, Honma M5, Chen T4, Moore MM4. 1Division of Systems Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States, 2Center for Food Safety and Applied Nutrition, FDA, College Park, MD, United States, 3University of Arkansas for Medical Sciences, Little Rock, AR, United States, 4Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR, United States, 5National Institue of Health Sciences, Tokyo, Japan.
P31
Riddelliine Induced Rat Liver Mutagenicity and Gene Expression Profile
Mei N1, Guo L2, Fuscoe JC2, Chen T1. 1Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, United States, 2Division of Systems Toxicology, National Center for Toxicological Research, Jefferson, AR, United States.
P33
Mechanism of Inhibition of Arsenite Cocarcinogenesis by Supplemental Selenium (Se)
Rossman TG, Uddin AN, Burns FJ, Vega K. New York University School of Medicine, Tuxedo, NY, United States.
P35
The Potential Carcinogenic Effects of Some Tryptophan Metabolites
Chung K-T, Gadupudi GS. The University of Memphis, Memphis, TN, United States.
P37
Human Toxicogenomic Analysis of Bromoacetic Acid: A Regulated Drinking Water Disinfection By-Product
Wagner ED1, Muellner MG2, Hudson ME1, Attene-Ramos MS1, Plewa MJ1. 1University of Illinois, Urbana, IL, United States, 2Nalco Company, Naperville, IL, United States.
P39
Gene Selection and Gene Identification in Microarray Data Analysis
Chen JJ, Zou W, Chang C-W, Morris SM. National Center for Tox Res, Jefferson, AR, United States.
P41
Validation of Transgenic Rodent Gene Mutation Assays Using DNA Sequence Data
Douglas GR1, Soper LM1, Singer TM2. 1Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada, 2New Substances Assessment and Control Bureau, Health Canada, Ottawa, ON, Canada.
P43
Mutant T-cells in Melanoma Patients: Probes for Immunological Responses
Albertini MR1,2, Macklin MD2, Zuleger CL2, Newton MA2, Albertini RJ3. 1William S. Middleton Veterans Hospital, Madison, WI, United States, 2University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, WI, United States, 3University of Vermont, Burlington, VT, United States.
P45
Bystander Responses Induced by Mitomycin C, Phleomycin and Ionizing Radiation in Normal Human Lymphoblastoid Cells
Asur R, Thomas RA, Tucker JD. Wayne State University, Detroit, MI, United States.
P47
GPI-deficient Rat Lymphocytes Have Mutations in the Pig-A Gene
Miura D1, Mittelstaedt RA2, Shaddock JG2, Dobrovolsky VN2, Heflich RH2. 1Teijin Pharma Limited, Tokyo, Japan, 2USFDA/National Center for Toxicolgocal Research, Jefferson, AR, United States.
P49
The Effect of Reduced Levels of Human DNA Polymerase β on Microsatellite Mutagenesis in Human Cells
Jacob KD1, Sobol RW2, Eckert KA1. 1The Pennsylvania State University College of Medicine, Hershey, PA, United States, 2The University of Pittsburgh, Pittsburgh, PA, United States.
P51
Evaluation of cII Mutations in Big Blue Mice Fed Methylphenidate Hydrochloride for Up To 24 Weeks
Shelton SD1, Manjanatha MG1, Mattison DR2, Morris SM1. 1National Center for Toxicological Research/FDA/DGRT, Jefferson, AR, United States, 2National Institute of Child Health and Human Development, Bethesda, MD, United States.
P53
Cytotoxicity and Mitochondrial Membrane Damage Effects of Di-ethylhexyl and Mono-ethylhexyl Phthalates on Human TK-6 Lymphocyte Cells
Rosado C, Velez C, Zayas B. Metropolitan University, San Juan, Puerto Rico.
P55
Randon Mitochondrial Mutations in Human Age-Dependent Pathologies
Vermulst M1, Bielas J1, Wanagat J1, Kujoth G2, Prolla T2, Rabinovitch P1, Loeb L1. 11Department of Pathology, University of Washington, Seattle, WA, United States, 22Department of Medical Genetics, University of Wisconsin, Madison, WI, United States.
Environmental Genotoxins and Risk Assessment
P57
Induction of DNA Repair Ogt-alquil Enzymes by Roheo Discolor, Antimutagenic Ethanolic Extract
Arriaga-Alba M1, Gonzales-Avila M3, Ruiz-Perez NJ1, Sanchez-Navarrete J1. 1Hospital Juarez DE MEXICO, Mexico DF, Mexico, 3Universidad Politecnica de Pachuca, Pachuca-Cd Sahagún, Zempoala Hidalgo, Mexico.
P59
Genotoxic Exposure Assessment in Depleted Uranium (DU) Exposed Gulf War I Veterans: Sixteen Years of Follow Up
McDiarmid MA1,2, Gucer P1,2, Oliver M1,2, Engelhardt SM2, Squibb KS1,2, Dorsey C1,2, Vacek PM3, Ardell SK3, Albertini RJ3. 1University of Maryland, Baltimore, MD, United States, 2Department of Veterans Affairs Medical Center, Baltimore, MD, United States, 3University of Vermont, Burlington, VT, United States.
P61
Polymorphisms (SNPs) in DNA Repair Genes and Bladder Cancer Risk
Michiels S1, Laplanche A1, Boulet T1, Dessen P3, Guillonneau B5, Méjean A6, Desgrandchamps F7, Lathrop M4, Sarasin A3, Benhamou S2,3. 1Institut Gustave Roussy, Villejuif, France, 2INSERM U794, Paris, France, 3CNRS FRE2939, Villejuif, France, 4Centre National de Génotypage, Evry, France, 5Institut Mutualiste Montsouris, Paris, France, 6Hôpital Necker, Paris, France, 7Hôpital Saint-Louis, Paris, France.
P63
Flow Cytometric Determination of the Micronucleus Frequency in Juvenile Rhesus Monkeys Chronically Exposed to Methylphenidate Hydrochloride
Bishop ME1, Hotchkiss CE3, Lin C-J2, Chen JJ2, Mattison DR4, Morris SM1. 1DGRT/NCTR/FDA, Jefferson, AR, United States, 2DPMN/NCTR/FDA, Jefferson, AR, United States, 3WANPRC/UWashington, Seattle, WA, United States, 4OPP/NICHD/NIH, Bethesda, MD, United States.
P65
Functional Food Potential of Fermented Red Wine Pomace
Yoshikawa K. Kinki University, Nara City, Japan.
P67
Frequency of Chromosomal Aberrations in Prague's Mothers and Their Newborns
Sram RJ1, Rossnerova A1, Balascak I2. 1Institute of Experimental Medicine AS CR, v.v.i., Prague, Czech Republic, 2Faculty of Medicine, Charles University, Prague, Czech Republic.
P69
Development of an Automated In Vitro Micronucleus Analysis Method in CHL/IU Cells
Muto S, Sugiura K, Kurabe M, Aruga C, Yamamura E, Uno Y. Mitsubishi Tanabe Pharma Corporation, Kisarazu, Chiba, Japan.
P71
Coupling Cytotoxic Biomarkers with In Vitro Comet Assay
Shi J, Springer S, Bruce S, Sly J, Scherer M, Cecil M, Pant K, Escobar P. BioReliance Corporation, Rockville, MD, United States.
P73
Evaluation of Micronucleus Frequencies and DNA Damage in Male Rats Administered Methylphenidate Hydrochloride (Ritalin) for 28 Days
Witt KL1, Recio L2, Shepard K2, Green A2, Baldetti C2, Winters J2, Davis J3, Caspary W1, Hobbs CA2. 1National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States, 2Genetic Toxicology Division, ILS, Inc., Research Triangle Park, NC, United States, 3Integrative Toxicology Division, ILS, Inc., Research Triangle Park, NC, United States.
P75
Cytotoxicity and Mutagenicity of Stereoisomers of 3-Epoxybutane-1, 2-diol at Low Concentrations in TK6 Cells
Meng Q1, Hackfeld L2, Hodge R2. 1Battelle Toxicology Northwest, Richland, WA, United States, 2University of Texas Medical Branch at Galveston, Galveston, TX, United States.
P77
Cytotoxic and Genotoxic Potential of Surface and Waste Waters Using the Allium and Comet Tests
Radic S1, Stipanicev D2, Cvjetko P1, Širac S2, Marijanovic Rajcic M2, Pevalek-Kozlina B1, Pavlica M1. 1University of Zagreb, Zagreb, Croatia, 2Hrvatske vode-Legal entity for water management, Zagreb, Croatia.
P79
Identification Of Promutagens Using ‘S9’, Hepatocytes And HepaRG Cells, With The GADD45aGFP Genotoxicity Assay
Walmsley RM1,2, Tate M2, Jagger C2, Rabinowitz A2, Hughes C2, Cahill PA2, Knight AW2, Billinton N2. 1University of Mancheser, Manchester, United Kingdom, 2Gentronix Ltd, Manchester, United Kingdom.
P81
Cyclophosphamide and Etoposide Canine Studies Demonstrate the Cross-Species Potential of the Peripheral Blood Micronucleated Reticulocyte Endpoint
Torous D1, McKeon M2, Schmuck G3, Xu Y2, Burgess S2, Avlasevich S1, Dertinger S1, Kirkland D4. 1Litron Laboratories, Rochester, NY, United States, 2Covance, Vienna, VA, United States, 3Bayer Healthcare, Wuppertal, Germany, 4Covance, Harrogate, United Kingdom.
P83
The Mutagenic Activity of High-Energy Explosives, Contaminants of Concern at Military Training Sites
McAllister JE1,2, Gingerich JD1, White PA1. 1Health Canada, Ottawa, ON, Canada, 2University of Ottawa, Ottawa, ON, Canada.
P85
The Effect of Heat Shock on DNA Integrity in Leaves of Nicotiana tabacum L
Cvjetko P, Balen B, Peharec P, Pavlica M. University of Zagreb, Zagreb, Croatia.
P87
Time Course of Chemical-Induced In Vivo Genotoxicity Evaluated Using a Combined Protocol for Micronucleus and Comet Analyses
Hobbs CA1, Recio L1, Shepard K1, Winters J1, Green A1, Baldetti C1, Streicker M1, Davis J1, Caspary W2,3, Witt KL2,3. 1Integrated Laboratory Systems, Research Triangle Park, NC, United States, 2Toxicology Branch, NIEHS, Research Triangle Park, United States, 3National Toxicology Program (NTP), Research Triangle Park, United States.
P89
Study of Genotoxicity and Oxidative Stress Biomarkers in Rats Exposed to Toluene, Chloroform, Methylene Chloride and a Mixture of Them
Belmont JA1, Serrano L1, Fanjul ML2, Prieto J2, Montero RD1. 1Instituto de Investigaciones Biomedicas, U.N.A.M., Mexico, DF, Mexico, 2Facultad de Ciencias, U.N.A.M., Mexico, DF, Mexico.
P91
Carcinogen Exposure, Mutant DNA Biomarkers, and Human Cancer Risk
Sampliner DS, Elespuru RK. Food and Drug Administration, Silver Spring, MD, United States.
P93
Mutagenicity Study of Jet Fuels and Their Additives Using the Ames Salmonella Assay
Blanco-Yu FB. Seton Hill University, Greensburg, PA, United States.
P95
Automated Analysis of Micronuclei in Binucleate Human Lymphocytes
Norppa H, Järventaus H, Lindberg H, Falck G. Finnish Institute of Occupational Health, Helsinki, Finland.
P97
Revision of ICH S2 Guidance: J&JPRD Experience With Integrated Approaches for In Vivo Genotoxicity Assesment
van der Leede BM, De Boeck M, Van Goethem F, Van Gompel J. Johnson & Johnson Pharmaceutical Research & Development, a division of Janssen Pharmaceutica N.V., Beerse, Belgium.
P99
Syrian Hamster Embryo (SHE) Cell Transformation Assay (CTA) With Conditioned Medium Without Any X-Ray Irradiated Feeder Cells
Pant K1, Bruce SW1, Sly JE1, San RHC1, Scott A2, Carmichael P2. 1BioReliance Corporation, Rockville, MD, United States, 2SEAC Unilever, Colworth Sharnbrook Bedford, United Kingdom.
P101
“False” Positive Reduction in In Vitro Genotoxicity Assays, Estimation of Toxicity and Implications for Selection of Maximum Dose
Fowler P, Jeffrey L, Young J, Kirkland D. Covance Laboratories LTD, Harrogate, UK, United Kingdom.
P103
Biomarkers in the In Vivo Human Lymphocyte Micronucleus Test in Relation to Metabolic Polymorphisms of Enzymes CYP1A1, CYP2E1, GSTT1, GSTM1 and NQO1
Suarez K, Davila VM, Serrano L, Montero RD. Instituto de Investigaciones Biomedicas, U.N.A.M., Mexico, DF, Mexico.
P105
Defining Criteria for the Evaluation of the Ames II™ Mutagenicity Assay
Bruce SW, Sly JE, Cecil MW, Springer SD, Klug ML, Scherer MC, Pant K. BioReliance Corporation, Rockville, MD, United States.
P107
Genotoxicity of Acrylamide and Glycidamide in Big Blue Rats
McDaniel LP1, Dobrovolsky VN1, Shaddock JG1, Mei N1, McGarrity LJ1, Miura D2, Doerge DR1, Heflich RH1. 1U.S. FDA/NCTR, Jefferson, AR, United States, 2Teijin Pharma, Tokyo, Japan.
P109
Interpreting Data From In Vitro Genotoxicity Tests Using the Acellular Comet Assay
Dewhurst NE, Vasquez MZ. Helix3, Inc., Morrisville, NC, United States.
P111
Comparison of the Cytotoxicity and Mitochondrial Membrane Permeability of Benzazolo[3,2-a]quinolinium (BQs) on Tumor vs Normal Cell Lines
Molina D1, Velez C1, Carro S3, Hernandez W2, Arroyo LV1, Cox O2, Zayas B1. 1Metropolitan University, San Juan, Puerto Rico, 2University of Puerto Rico, San Juan, Puerto Rico, 3University of North Carolina, Chapel Hill, NC, United States.
P113
Monitoring of Environmental Polycyclic Aromatic Hydrocarbons (PAH) in Soil and Fish From the Cucharillas Marshland, Catano, Puerto Rico
Nieves P, Lopez WL, Zayas B. Metropolitan University, San Juan, PR, United States.
P115
Combined Use of Multiple Biomarkers to Evaluate the Genotoxic Activity of the Herbicide Glyphosate
Ramos-Morales P, Muñoz JA, Rivas H, Muñoz A, Hernandez BR, Herrera JJ, Muñoz LB. Lab Genetica y Toxicologia Ambiental, Fac Ciencias, Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico.
DNA Repair and Damage Responses
P117
Dynamic Compartmentalization of BER Proteins into Nuclei and Mitochondria is Governed by Oxidative DNA Damage Levels and Sumoylation
Griffiths LM, Swartzlander D, Wilkinson KD, Corbett AH, Doetsch PW. Emory University, Atlanta, GA, United States.
P119
Identifying Novel Human Damage Response Proteins Based on Yeast Orthology. Svensson P, Rebecca Fry R, Samson LD. Biological Engineering Department and Center for Environmental Health Sciences, MIT, Cambridge, MA, United States.
|
General Information