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DNA Repair and Damage Responses
P2
Homologous Recombination Contributes Substantially to Base-Substitution Mutagenesis in Mammalian Cells
Hinz JM, Urbin SS, Thompson LH. Lawrence Livermore National Laboratory, Livermore, CA, United States.
P4
Hypersensitivity of Mitochondrial Mutant Cells to Ionizing Radiation, Phleomycin and Mitomycin C
Kulkarni RM, Reither A, Thomas RA, Tucker JD. Wayne State Univeristy, Detroit, MI, United States.
P6
Chromodomain Helicase DNA Binding Protein 2 and DNA Damage Response Signalling
Rajagopalan S1, Nagarajan P1, Mahadevan B3, McDonald H2, Matteson KJ1, Venkatachalam S1. 1University of Tennessee, Knoxville, TN, United States, 2Oak Ridge National Laboratory, Oak Ridge, TN, United States, 3Schering-Plough Research Institute, Summit, NJ, United States.
P8
Limited Base Excision Repair in C. elegans
Lehmann DW, Asagoshi K, Prasad R, Wilson SH, Van Houten B. National Institute of Environmental Health Sciences, Durham, NC, United States.
P10
The Oxidative DNA Lesions, 8,5’-Cyclo-2'-Deoxyadenosine and 8-Oxo-7,8 Dihydro-2'-Deoxyadenosine, Differentially Alter the Binding of HSF1 and CREB Transcription Factors to Target DNA Sequences
Abraham J, Brooks P. National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States.
P12
Genetic Susceptibility to Ionizing Radiation Induced Tumor and DNA Strand Break Repair in p53 Deficient and Wildtype Mouse Hematopoiectic Stem Cells (HSC) In Vivo and In Vitro
French JE, Parron VI. NIEHS, NIH, Research Triangle Park, NC, United States.
P14
Modeling the Expression Pathway Controls of the Radioadaptive Response Across Tissues in Mice
Bhattacharya S, Poylzos AA, Bhatnagar S, Chu SD, Lowe XR, Marchetti F, Wyrobek AJ. Lawrence Berkeley National Lab, Berkeley,CA, United States.
Epigenetics
P16
Effects of Irradiation on DNA Methylation and Genomic Instability
Aypar U, Malkiel LN, Baulch JE. University of Maryland, School of Medicine, Baltimore, MD, United States.
P18
Spontaneous Mutagenesis Frequencies Correlate with AP Endonuclease Abundance in Murine Spermatogenic Cells
Perez M1, Hildreth K1, Herbert DC1, McMahan CA1, Izumi T3, Mitra S3, Walter CA1,2. 1University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2South Texas Veteran's Health Care System, San Antonio, TX, United States, 3University of Texas Medical Branch at Galveston, Galveston, TX, United States.
P20
Mutagen-Exposed Female Germ Cells Mediate Delayed Mutagenesis in Early Stage Embryos
Gresham CS, Norris MB, Winn RN. ABEL University of Georgia, Athens, GA, United States.
P22
Tissue-Selective and Sex Differences in Brain of Mice Exposed to Ionizing Radiation
Koturbash I1, Kutanzi K1, Kolb B2, Kovalchuk O1. 1University of Lethbridge, Lethbridge, AB, Canada, 2Canadian Centre for Behaviour Neuroscience, Lethbridge, AB, Canada.
P24
DMN Disturbs Sex Differentiation and Induces Transgenerational Damage From Affected Males
Ramos-Morales P, Vega CC. Lab Genetica y Toxicologia Ambiental, Fac Ciencias, Universidad Nacional Autonoma de Mexico, Distrito Federal, Mexico.
Mutagenesis and Carcinogenesis
P26
Maternal Dioxin Exposure Combined with a Diet High in Fat Increases Mammary Cancer Incidence Through Induction of Estrogen Metabolizing Genes CYP1B1 and COMT
La Merrill M1,2, Harper R1, Birnbaum L3,1, Cardiff R4, Threadgill D1. 1University of North Carolina, Chapel Hill, NC, United States, 2Mt Sinai School of Medicine, New York, NY, United States, 3US EPA, Research Triangle Park, NC, United States, 4University of California, Davis, CA, United States.
P28
Abstract Withdrawn
P30
High Levels of Transcription Stimulate Base Substitution Mutations in Yeast
Lippert MJ, Alexander MP, Crall WC, Holmes MP. Saint Michael's College, Colchester, VT, United States.
P32
DGGE-Based Detection of Mitochondrial tRNA Gene and Flanking Region Mutations in Umbilical Cord Tissue from HIV-1 Uninfected Infants Receiving Perinatal AZT-Based Therapies
Torres SM1,2, Walker DM3, Seilkop SK4, Copeland WC5, Walker VE1,3. 1Lovelace Respiratory Research Institute, Albuquerque, NM, United States, 2University of New Mexico, Albuquerque, NM, United States, 3BioMosaics Inc., Burlington, VT, United States, 4SKS Consulting Services, Silver City, NC, United States, 5NIEHS, National Institutes of Health, Research Triangle Park, NC, United States.
P34
Comparison of MicroRNA Expression, Genomic Gene Expression, DNA Adducts, Mutation Induction, and Tumor Incidence for Carcinogenesis of Aristolochic Acid in Rat Kidney
Chen T, Pearce M, Mei N, Guo L. National Center for Toxicological Research, FDA, Jefferson, AR, United States.
P36
Gene Expression of Phase I and Phase II Metabolizing Enzymes and PAH-DNA Adduct Formation in Human Prostate as Risk Factors in Prostate Cancer Etiology
John K1, Singh PB2, Pratt MM1, Ragavan N2, Cole KC3, Matanhelia SS3, Phillips DH3, Martin FL2. 1National Cancer Institute, NIH, Bethesda, MD, United States, 2Lancaster University, Lancaster, United Kingdom, 3Institute of Cancer Research, Surrey, United Kingdom.
P38
Genotoxicity of Titanium Dioxide (TiO2) in Human Bronchial Epithelial Cells In Vitro
Falck GC-M1, Lindberg HK1, Suhonen S1, Vippola M2, Vanhala E1, Savolainen K1, Norppa H1. 1Finnish Institute of Occupational Health, Helsinki, Finland, 2Tampere University of Technology, Tampere, Finland.
P40
Proteomic Profiling of Urinary Bladders From Mice Exposed to Sodium Arsenite
Winnik WM, Chilakapati J, Wallace K, Kitchin KT, Ortiz PA. U.S. Environmental Protection Agency, Research Triangle Park, NC, United States.
P42
Abundant Expression of CYP1A1 isPositively, While CYP1B1 and NQO1 Are Negatively, Associated With Benzo(a)pyrene (BP)-DNA Adduct Formation in Normal Human Mammary Epithelial Cells (NHMECs)
Einem TL1, Divi RL1, Shockley ME1, Keshava C2, Weston A3, Poirier MC1. 1National Cancer Institute, NIH, Bethesda, MD, United States, 2U.S. EPA, Research Triangle Park, NC, United States, 3NIOSH, CDC, Morgantown, WV, United States.
P44
Exploration of the Composition of Chromatin Buds in the In Vitro Human Lymphocyte Micronucleus Test
Araujo AT, Serrano L, Camacho R, Montero RD. Instituto de Investigaciones Biomedicas, UNAM, Mexico, DF, Mexico.
P46
Cell Proliferation of Pancreatic β-cells is Impaired by Arsenite Treatment
Sordo M1, Burns AL1,2, Salazar A1, Ostrosky-Wegman P1, Diaz-Villaseñor A1. 1Instituto de Investigaciones. UNAM, México DF, Mexico, 2Facultad de Medicina. UNAM, México DF, Mexico.
P48
Depressed Antioxidant Status in Pregnant Women on Iron Supplements: Mutagenic Implications
John A, Fidelia A, Grace T, Abiodun A, Fasola FA. University of Ibadan, Ibadan, Oyo, Nigeria.
P50
Thymidylate Synthase: Tumor Suppressor and Oncogene in Sporadic Breast Cancer?
Barclay B1, Murray D2. 1Planet Biotechnologies Inc, St Albert, AB, Canada, 2Cross Cancer Institute, Edmonton, AB, Canada.
P52
Arrest of Mitochondrial RNA Polymerase by the Malondialdehyde Adduct, M1dG
Cline SD1, Lodeiro MF2, Marnett LJ3, Cameron CE2, Arnold JJ2. 1Mercer University School of Medicine, Macon, GA, United States, 2Penn State University, State College, PA, United States, 3Vanderbilt University School of Medicine, Nashville, TN, United States.
P54
Gene Polymorphisms and the Risk of Head and Neck Squamous Cell Carcinoma in Brazil
Garcia SMN1, Curioni OA2, Brasilino M2, Kohler P1, Gattás GJF1. 1FMUSP, São Paulo, Brazil, 2Heliopolis Hospital, Sâo Paulo, Brazil.
P56
Nuclear and Mitochondrial Mutations in Cancer
Bielas JH1, Vermulst M1, Fox EJ2, Ericson NG1, Loeb KR3, Rubin BP4, O'Sullivan JN2, True LD1, Loeb LA1. 1Department of Pathology, University of Washington, WA, United States, 2Centre for Colorectal Disease, Department of Gastroenterology, St. Vincent’s University Hospital, Department of Medicine, University College Dublin, Dublin, Ireland, 3Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, United States, 4Department of Anatomic Pathology and Department of Molecular Genetics, Taussig Cancer Center and the Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Environmental Genotoxins and Risk Assessment
P58
Antimutagenic Properties of Group B Vitamins
Arriaga-Alba M, Ruiz-Perez N-J, Sanchez-Navarrete J, Lopez Del Angel B, Flores-Lozada J. Hospital Juarez De Mexico, Mexico DF, Mexico.
P60
The Role of Dietary Micro-Nutrient Supplementation to Maintain Genomic Stability
Vaglenov A1,2, Shinn B1, Edelbrock M3, Schwaner T3, Simonian A4. 1School of Pharmacy, University of Findlay, Findlay, OH, United States, 2National Center of Radiobiology and Radiation Protection, Sofia, Bulgaria, 3College of Sciences, University of Findlay, Findlay, OH, United States, 4College of Engineering, Auburn University, Auburn, AL, United States.
P62
The Mutagenicity and Dioxin-Like Activity of Biodiesel Emissions
Gagnon ML, White PA. Health Canada, Ottawa, ON, Canada.
P64
Antioxidant and Anticlastogenic Capacity of Prickly Pear Juice
Hernández-Ceruelos A, Madrigal-Santillán E, Valadez-Vega C. Intituto de Ciencias de la Salud, Area Académica de Medicina, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico.
P66
Genotoxicity of Methylphenidate Hydrochloride in the Rhesus Monkey
Dobrovolsky VN1, Shaddock JG1, Manjanatha MG1, Miura D3,1, Mattison DR2, Morris SM1. 1NCTR, Jefferson, AR, United States, 2NICHD, Bethesda, MD, United States, 3Teijin, Tokyo, Japan.
P68
Enhancement of Bleomycin Genotoxicity in Yeast by Conventional and Unconventional Intercalating Agents
Hoffmann GR, Laterza AM, Sylvia KE, Tartaglione JP. College of the Holy Cross, Worcester, MA, United States.
P70
Flow Cytometric Evaluation of Micronucleated Polychromatic Erythrocytes in Bone Marrow and Micronucleated Reticulocytes in Peripheral Blood Following Acute and Repeat Dosing Regimen of Chemicals
Shi J1, Krsmanovic B1, Torous D2. 1BioReliance Corporation, Rockville, MD, United States, 2Litron Laboratories, Rochester, NY, United States.
P72
Cross-Validation of Miniature Ames and In Vitro Micronucleus Assays to Facilitate Earlier Genotoxicity Screening During Lead Optimization
Sawant SG1, Pant K2, Szkudlinska A2. 1Amgen Inc., Thousand Oaks, CA, United States, 2BioReliance Corporation, Rockville, MD, United States.
P74
Miniaturization and Further Automation of the In Vitro Micronucleus Assay
Bryce S, Phonethepswath S, Avlasevich S, Bemis J, Dertinger S. Litron Laboratories, Rochester, NY, United States.
P76
A Mini Version of the Mouse Lymphoma Cell Thymidine Kinase Locus Assay
Hou S, Bjurström M, Bolcsfoldi G. Safety Assessment, AstraZeneca R&D Södertälje, Södertälje, Sweden.
P78
Mouse Mutation Assay Based on the Pig-a Gene
Phonethepswath S, Bryce S, Bemis J, Dertinger S. Litron Laboratories, Rochester, NY, United States.
P80
Impaired Mitochondrial Function May Cause Liver Toxicity in Nevirapine-Treated B6C3F1 Mice
Desai VG, Moland CL, Lee T, Branham WS, Beland FA, VonTungeln LS, Fuscoe JC. NCTR, Jefferson, AR, United States.
P82
Dietary Polyphenols as Topoisomerase II Poisons: B Ring and C Ring Substituents Determine the Mechanism Of Enzyme-Mediated DNA Cleavage Enhancement
Bandele OJ, Clawson SJ, Osheroff N. Vanderbilt University School of Medicine, Nashville, TN, United States.
P84
Genotoxicity of Carbon Nanomaterials In Vitro
Lindberg HK1, Falck GC-M1, Suhonen S1, Järventaus H1, Catalán J1,2, Vippola M1,3, Vanhala E1, Savolainen K1, Norppa H1. 1Finnish Institute of Occupational Health, Helsinki, Finland, 2University of Zaragoza, Zaragoza, Spain, 3Tampere University of Technology, Tampere, Finland.
P86
Validation of a Multi-Endpoint Assay in Rats: Bone Marrow Micronucleus, Comet and Flow Cytometric Peripheral Blood Micronucleus
Bowen D1, Henderson D1, Kidd D1, McGarrey S1, Pearce G1, Torous D2, Whitwell J1, Williams L1, Kirkland D1. 1Covance Laboratories, Harrogate, United Kingdom, 2Litron Laboratories, New York, NY, United States.
P88
Dose-Response Relationship, Kinetics of Formation and Persistence of s-[2-(N7-guanyl) ethyl]glutathione DNA Adduct in Livers of Channel Catfish (Ictalurus punctatus) Exposed In Vivo to 1, 2-Dichloroethane
Means JC1, Jemal A2. 1Southern Illinois University, Carbondale, IL, United States, 2American Cancer Society, Atlanta, GA, United States.
P90
Evaluation of the Butter Flavoring Diacetyl and the Fluorochemical Paper Additive Lodyne P-280â For Mutagenicity
Whittaker P2, Begley TH2, Clarke JJ1, San RH3, Dunkel VC4. 1BioReliance, Rockville, MD, United States, 2US FDA, College Park, MD, United States, 3Consultant, Gaithersburg, MD, United States, 4Consultant, Bethesda, MD, United States.
P92
A Novel Mutagenic Potency Ratio Method to Assess the Excess Lifetime Cancer Risk of Complex PAH Mixtures in Contaminated Soils
Lemieux CL1, Long A1, Lundstedt S2, Tysklind M2, Lambert IB3, White PA1. 1Mechanistic Studies Division, Safe Environments Programme, HECSB, Health Canada, Ottawa, ON, Canada, 2Department of Chemistry, University of Umeå, Umeå, Sweden, 3Department of Biology, Carleton University, Ottawa, ON, Canada.
P94
Mutagenic Effects of Acrylamide and Glycidamide in the Testes of Big Blue Mice
Azuma M, McDaniel L, Manjanatha M, Shelton S, Mei N. Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, Jefferson, AR, United States.
P96
Micronucleus Frequency in Hamsters Peripheral Blood
Salazar AM1, López-Cuevas E1, León S2, Flisser A2, Ostrosky-Wegman P1. 1Instituto de Investigaciones Biomedicas. UNAM, México DF, Mexico, 2Facultad de Medicina, Mexico DF, Mexico.
P98
Reduction of False Positives in In Vitro Genotoxicity Assays
Fowler P, Jeffrey L, Young J, Kirkland D. Covance Laboratories Ltd, Harrogate, UK, United Kingdom.
P100
Skin and Lung Comet Assays: Current Developmental Status
Williams L, McGarry S. Covance Laboratories Ltd, Harrogate, UK, United Kingdom.
P102
Combined Protocol for Simultaneous Measurement of Micronucleated Erythrocyte Frequencies and DNA Damage in Rodents
Recio L1, Hobbs-Riter C1, Shepard K1, Baldetti C1, Streicker M1, Winters J1, Caspary W2, Witt KL2. 1ILS, Research Triangle Park, NC, United States, 2NTP NIH NIEHS, Research Triangle Park, NC, United States.
P104
Validation of the In Vitro Micronucleus Assay and Fluorescent In Situ Hybridization (FISH) in Human Lymphocytes
Farabaugh CS, Roberts DJ, Roy SK, Middendorf CA, Stankowski, Jr LF. Covance Laboratories, Inc., Vienna, VA, United States.
P106
Application of the Acellular Comet Assay to Genotoxicity Testing for Pharmaceuticals
Vasquez MZ. Helix3 Inc., Morrisville, NC, United States.
P108
Validation of Flow Cytometry to Assess Mitotic Index in the Human Lymphocyte Chromosome Aberration Assay
Roberts DJ, Middendorf CA, Stojhovic G, Roy SK, Stankowski Jr LF. Covance Laboratories, Vienna, VA, United States.
P110
Target Organ Selection for the In Vivo Comet Assay: Genotoxicity Versus Tumorigenesis
Sivers CL, Vasquez MZ. Helix3 Inc., Morrisville, NC, United States.
P112
Detection of Weak Mutagens in Transgenic Rodent Mutation Assays: Challenging the International Workshops on Genotoxicity Testing Protocol Recommendations
Singer TM1,2, Douglas GR1, Gingerich JD1, Williams A3, Soper L1, Lambert IB2. 1Mutagenesis Section, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada, 2Department of Biology, Carleton University, Ottawa, ON, Canada, 3Biostatistics Section, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
P114
Effect of Carbon Nanotubes—DNA Interaction on the Cellular Genomic Stability
Barajas Lemus C, Camacho Carranza R, Espinoza Aguirre J, Hernandez Ojeda SL. Instituto de Investigaciones Biomedicas UNAM, México, Mexico.
P116
Potential Role of Environmental Mutagens in the Development of Human Lymphoid Malignancies
DeVoney D, Sonawane B, Jinot J, Bateson T, Vandenberg J. National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, D.C., United States.
DNA Repair and Damage Responses
P118
Mapping the Localization of DNA Repair Machinery to Sites of Genomic DNA Damage and Chromosomal Instability in Saccharomyces cerevisiae
Morris LP, Degtyareva N, Doetsch PW. Emory University, Atlanta, GA, United States.
P120
Analyzing Genetic Interactions to Elucidate DNA Damage Responsive Networks and Toxicity Mechanisms of Environmental Agents in Yeast. Quirós L, Svensson P, Wang E, Fry R, Samson LD. Biological Engineering Department and Center for Environmental Health Sciences. MIT, Cambridge, MA, United States.
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